Implantable brain–computer interfaces (BCIs) promise to be a viable means to restore communication in individuals with locked-in syndrome (LIS). For future clinical implementation of implantable communication-BCIs, there is a need to validate systems in daily life settings with more participants, and to improve the speed of communication. The paper provides an overview of procedures, as well as recommendations, for recruitment, screening, inclusion, imaging, hospital admission, implantation, training, and support of participants with LIS, for studies on daily life implementation of implantable communication-BCIs. Read more about Implantable brain–computer interfaces.